COVID-19

Longer term issues

Sequelae

One in ten are sick for three weeks or more

COVID-19, short term illness caused by SARS-CoV-2

Most health sources, people will recover within two weeks

Some people report symptoms from 3 weeks to months

Trigger diabetes?

Several anecdotal reports of spontaneous diabetes mellitus type 1 after COVID infection

Evidence of beta cell damage in vitro and small animal studies

Direct or indirect damage

Insulin lack

Weight loss, thirst, polyuria

Tiredness, blurred vision, local infections, ketosis

Pulmonary fibrosis

Symptoms associated with acute COVID-19, mild upper respiratory tract symptoms to severe acute respiratory distress syndrome

Data from SARS and MERS
Emerging data from the COVID-19 pandemic

Could be substantial fibrotic consequences following SARS-CoV-2 infection

Idiopathic pulmonary fibrosis

Antifibrotic therapies, possible role in treatment

Might have a role in preventing fibrosis after SARS-CoV-2 infection.

Neurology

Around a third of ITU patients admitted for respiratory difficulties exhibit neurologic symptoms

? hypoxia
? inflammation
? SARS-CoV-2 dissemination into brain parenchyma

CoV infection can potentially lead to chronic neuroinflammation and progressive demyelination

Sensorimotor dysfunctions
Psychiatric disorders
Brain cell degeneration and demyelination