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This video is an in-depth scientific explanation of why a certain percentage of the population is susceptible to COVID-19. Doctors and scientists start to realise that it is a dysfunction of the endothelium that mainly result in death in COVID-19. This video explains that it is the degree of sulfation of the glycocalyx that will affect viral entry into the cell, modulation of the immune response and the attenuation and dysfunction of the endothelial cells.
The video highlights the main factors which affect the degree of sulfation, namely diet, digestion and absorption, pollution, toxicity, gut dysbiosis and prescription medication, such as non-steroidal anti-inflammatory drugs. Genetic variability will also be a factor.
The original scientific article, ‘Why anti-inflammatory drugs are contraindicated in COVID-19’, was first published online on the 25th March 2020. The updated version of the article can be accessed through this link:
The article has been submitted for scientific publication, but has not been accepted to date.
Summary of the article:
Glycosaminoglycans (GAGs) are complex linear, negatively charged polysaccharides, expressed at the cell surface, and in the extracellular environment, where they interact with various molecules to regulate many cellular processes implicated in health and disease. Subversion of GAGs is a pathogenic strategy shared by a wide variety of microbial pathogens, including viruses.
The degree of GAG sulfation plays an important role in the host defence system and immunomodulation. Anti-inflammatory drugs are dependent on sulfation for its metabolism. The sulfation of these drugs will deplete the endogenous sulfate levels, affecting the degree of sulfation of the GAGs, therefore impacting on the defence system and the immune response in the lung glycocalyx, predisposing to COVID-19 in SARS-CoV-2 infected individuals.
Keywords: COVID-19, SARS-CoV-2, non-steroidal anti-inflammatory drugs, glycosaminoglycans, sulfation
