Background: Low vitamin D level is associated with a higher risk and a more severe course of Crohn’s disease (CD). Varying doses of vitamin D can rapidly alter the serum levels of 25 hydroxy-vitamin D (25OHD). No study specifically addressed whether supplementation of 25OHD can modulate its long-term level and the relapse rate of CD in children.
Aim: To investigate if high dose oral vitamin D3 (VITD), as oral add-on therapy, improve the levels of 25OHD (greater than 100 nmol/L) without any adverse event and increase the rate of sustained corticosteroids free remission.
