Obesity is now defined as a disease state, and the American Society of Clinical Oncology endorses weight gain prevention and weight loss facilitation for all obese cancer patients,” the authors said.
Using data on 993 women that they obtained from the cancer toxicities trial, a large, contemporary, prospective trial, they focused on a 5% weight gain or loss from baseline in the time between diagnosis and the period immediately following primary treatment. Weight and BMI were initially measured at diagnosis (baseline) visit. The mean weight was 89.4 kg (range, 61.0-153.0), and the mean BMI, 34.5 kg/m2 (range, 30.0-59.0). Changes in HRQOL were assessed using the European Organisation for Research and Treatment of Cancer questionnaires QLQ-C30 and QLQ-BR23.
The mean (SD) patient age at diagnosis was 59.1 (10.5) years, the median (interquartile range [IQR]) time from diagnosis to post-treatment was 10.5 (IQR, 7.8-12.5) months, and most (79.6%) had hormone receptor-positive, human epidermal growth factor receptor 2–negative disease and underwent partial surgery (75.1%). In addition, 91.6% underwent radiation and 53.6%, adjuvant chemotherapy.
At the end of the study period, most (67.3%) of the women had maintained their weight, 14.1% had gained at least 5% from their baseline measure, and 18.6% lost more than 5% of their baseline weight. The women in this final group tended to be older (50-64 years), postmenopausal, and never-smokers.
Overall, the patients who lost weight had reduced odds of severe pain compared with those who gained weight (odds ratio [OR], 0.51; 95% CI, 0.31-0.86; P = .011) or whose weight remained stable (OR, 0.62; 95% CI, 0.41-0.95; P = .029). In addition, the group that lost weight had smaller mean drops in their HRQOL scores on the following measures compared with the stable-weight and weight-gain groups:
Physical function:
Lost: –6.2 (range, –8.7 to –3.7)
Stable: –6.9 (range, –8.2 to –5.5)
Gain: –12.9 (range –16.5 to –9.3)
Dyspnea:
Lost: 3.2 (range, –1.0 to 7.3)
Stable: 9.2 (range, 6.5-11.9)
Gain: 18.9 (range, 12.3-25.6)
Breast symptoms:
Lost: 13.4 (range, 9.0-17.2)
Stable: 18.0 (range, 15.7-20.3)
Gain: 22.1 (range, 16.8-27.3)
“Beyond impaired well-being, posttreatment functional decline leads to loss of independence, worse social and cost-related outcomes, and possibly impairs cancer-specific outcomes, while increased symptom burden is associated with higher rates of nonadherence to adjuvant treatment and worse social rehabilitation in breast cancer survivors,” they concluded. “Our results inform further studies aimed at testing whether weight control can modulate some of these negative consequences.”
Going forward they suggest a more intensive study of the effects of weight gain and loss in what they term the early survivorship period as a way “to mitigate many downstream sequelae of primary breast cancer treatment.”
Reference
Di Meglio A, Michiels S, Jones LW, et al. Changes in weight, physical and psychosocial patient-reported outcomes among obese women receiving treatment for early-stage breast cancer: a nationwide clinical study [published online April 11, 2020]. Breast. DOI: 10.1016/j.breast.2020.04.02.
————————————————————————————————————————
Eat What You Like & Lose Weight For Life: The Infographic Guide to the Only Diet that Works:
LOSE WEIGHT:
TheFitLife Exercise Resistance Bands with Handles – 5 Fitness Workout Bands Stackable up to 110 lbs, Training Tubes with Large Handles, Ankle Straps, Door Anchor Attachment, Carry Bag, and Bonus eBook
GET YOUR COMPLETE RESISTANCE BANDS SET NOW:
calliven Premium Super Kegel Exerciser – Pelvic Floor Muscle and Inner Thigh Exerciser, Correction Beautiful Buttocks Bladder Control Device Postpartum Rehabilitation
GET YOUR CALLIVEN PREMIUM SUPER KEGEL EXERCISER:
Sunny Health & Fitness SF-RW1205 12 Adjustable Resistance Rowing Machine Rower w/Digital Monitor
GET YOUR SUNNY HEALTH & FITNESS:
B Toner – At-Home Exercise Program for Upper Body Fitness, Tone Arms and Chest, Lift Breasts, Strengthen Posture
GET YOUR B TONER:
Evlution Nutrition BCAA Energy – Essential BCAA Amino Acids, Vitamin C, Natural Energizers for Performance, Immune Support, Muscle Building, Recovery, B Vitamins, Pre Workout, 30 Serve, Acai Berry
GET YOU EVLUTION:
Taimot Pilates Resistance Band Portable Pilates Bar Home Gym Stick Yoga Exercise Bar Pilates Total Body Workout Trainer Fitness Rod with Foot Loop for Bodybuilding Workout
GET YOUR TAIMOT PILATES RESISTANCE:
#workout #gymtimeservice #gymtime
YOUTUBE CHANNEL:
FACEBOOK:
MUSIC: CLUB STEP BY Topher Mohr and Elena
VIDEO EDITOR: Filmora9
