Vitamin D and Health: Newly Discovered Benefits, Beyond Bones. “Change your food change your life!”.
#vitamind #vitamindresearch #vitamindandcancer #vitamindbenefits #newdiscoveries #vitamindanddiabetes #vitamindandflu #vitamindandmultiplesclerosis #vitamindandtb. Truth about vitamin supplements. Untold secrets of vitamin D
Research on the role of vitamin D in disease prevention has garnered considerable attention, with a focus on determining the efficacy of doses exceeding the Recommended Dietary Allowance (RDA). Observational studies highlight a notable correlation between reduced disease rates in populations residing in sunnier regions or exhibiting higher vitamin D serum levels. However the outcomes of some clinical trials with vitamin D supplements are inconclusive.
Vitamin D and Bone & Muscle strength
Higher vitamin D intake, approximately 500-800 IU per day, reduced hip and non-spine fractures by approximately 20%. In contrast, lower intakes (400 IU or less) failed to exhibit any discernible fracture prevention benefits.
Beyond its role in bone health, vitamin D is implicated in enhancing muscle strength by preserving muscle fibers, a factor crucial in preventing falls—common occurrences leading to substantial disability and mortality among older individuals.
Vitamin D and Cancer Prevention
Geographic location, particularly latitude, has been linked to colon cancer mortality rates, with higher latitudes showing increased death rates. The connection is attributed to lower vitamin D levels due to weaker UVB rays at higher latitudes. Vitamin D enhance survival in individuals who develop cancer.
Vitamin D and Type 2 diabetes (T2DM):
Women with the highest vitamin D intake from supplements demonstrated a 13% lower risk of developing T2DM compared to those with the lowest intake. The protective effect was even more pronounced when vitamin D was combined with calcium.
Vitamin D and Immune system:
Vitamin D deficiency contributes to the onset of autoimmune diseases like multiple sclerosis and type 1 diabetes, where the immune system erroneously attacks the body’s own organs and tissues. vitamin D supplements could enhance the body’s immune defenses to combat infectious diseases, such as tuberculosis and seasonal flu.
the existing evidence strongly suggests that low vitamin D levels may play a causal role in MS. If this is indeed the case, correcting vitamin D insufficiency could potentially prevent around 40% of MS cases. Recent findings indicating that genetically determined low vitamin D levels predict a higher risk of multiple sclerosis further strengthen the connection between vitamin D and the development of this autoimmune disease.
Vitamin D and Type 1 diabetes:
A study found that children who regularly received vitamin D supplements during infancy had a nearly 90% lower risk of developing type 1 diabetes compared to those who did not receive supplements.
Seasonal Flue and Vitamin D:
Rate of type A influenza in the vitamin D trial group was approximately 40% lower than in the placebo group, with no significant difference in type B influenza rates.
Tuberculosis:
Historically, before the era of antibiotics, sunlight and sun lamps were integral components of the standard treatment for tuberculosis (TB). More recent research has explored the potential link between the “sunshine vitamin,” vitamin D, and the risk of TB.
Other autoimmune disease:
The Vitamin D and Omega-3 trial (VITAL), a randomized double-blind placebo-controlled trial tracking over 25,000 men and women aged 50 and older, revealed noteworthy findings regarding vitamin D supplementation. The trial showed that taking vitamin D supplements at a dosage of 2,000 IU/day for five years, either alone or in combination with marine omega-3 fatty acids (1,000 mg/day), led to a reduction in the incidence of autoimmune diseases by approximately 22% compared to a placebo.
Reduction in Overall Mortality:
vitamin D has also proven role in reduction of overall mortality.
Vitamin D and Cognitive Functions:
In an analysis involving over 427,000 White European participants using Mendelian randomization, it was found that individuals with low vitamin D blood levels had a 54% higher risk of dementia compared to those with adequate levels of 50 nmol/L. This approach, which employs genetic variations to establish causal relationships, helps provide robust evidence linking low vitamin D levels to an increased risk of cognitive decline.
Sources of vitamin D : https://youtu.be/J7gUuL96Nx8?si=hlBk_lyjxgT8psqw
Reference:
Harvard T.H. Chan, School of Public Health.
Chapters
00:00 Introduction
01:10 Vitamin D and Bone & Muscles
02:21 Vitamin D and Cancer
03:29 Vitamin D and Type 2 Diabetes
04:29 Vitamin D and Immune System
05:06 Multiple Sclerosis
07:13 Seasonal Flu and Vitamin D
10:30 Vitamin D and Type 1 Diabetes
11:59 Tuberculosis
12:34 Other autoimmune diseases
14:04 Reduction in Overall Mortality
14:41 Vitamin D and Cognitive Functions
In this video we’ll be uncovering the latest findings on the diverse roles of vitamin D that go beyond just keeping our bones strong from supporting the immune system to potential impacts on Mental Health cardiovascular health and more there’s a lot to explore so buckle up as we journey into
The Intriguing and evolving landscape of vitamin D research but before we dive in make sure to hit that subscribe button give us a thumbs up and ring the notification Bell so you never miss out on our latest content now let’s shed some light on the newly discovered roles of vitamin D
Research on the role of vitamin D in disease prevention has garnered considerable attention with a focus on determining the efficacy of doses exceeding the recommended dietary allowance RDA while observational studies highlight a notable correlation between reduced disease rates in populations residing in sunnier regions or exhibiting higher vitamin D serum levels
The outcomes of clinical trials administering Vitamin D supplements to Target specific diseases remain inconclusive vitamin D and bone and muscle strength a comprehensive metaanalysis involving 12 randomized controlled trials encompassing over 42,000 individuals aged 65 and above predominantly women scrutinize the impact of vitamin D supplementation with or without calcium the analysis revealed
That higher vitamin D intake approximately 500 to 800 IU per day reduced hip and non-spine fractures by approximately 20% in contrast lower intakes 400 IU or less failed to exhibit any discernable fracture prevention benefits Beyond its role in bone health vitamin D is implicated in enhancing muscle strength by preserving muscle
Fibers a factor crucial in preventing false common occurr es leading to substantial disability and mortality among older individuals a pulled analysis of multiple studies indicated that a daily intake of 700 to 1,000 IU of vitamin D lowered the risk of Falls by 19% whereas doses ranging from 200 to 600 IU did not
Offer such protection vitamin D and cancer geographic location particularly latitude has been linked to colon cancer mortality rate with higher latitudes showing increased death rates the connection is attributed to lower vitamin D levels due to weaker UVB rays at higher latitudes vitamin D has been studied for its potential to inhibit tumor
Development especially in organs like the colon while epidemiological studies support the idea that higher vitamin D levels are associated with lower cancer rates clinical trials like the women’s health initiative and vital have not consisted ly confirmed these associations vital did not find significantly different cancer rates between those taking vitamin D and the
Placebo group but suggested a potential survival benefit for those with higher vitamin D status as seen in reduced cancer related mortality over time the evidence indicates that while vitamin D may not be a primary factor in preventing cancer it could enhance survival in individuals who develop cancer vitamin D and type 2
Diabetes the impact of vitamin D deficiency on the biochemical Pathways leading to the development of type 2 diabetes t2dm is a subject of concern affecting beta cell function in the pancreas insulin resistance and inflammation observational Studies have highlighted an inverse relationship between higher vitamin D blood levels and the incidence of
T2dm in a comprehensive analysis of the nurse’s Health stud study involving over 83,000 women without diabetes at Baseline the association between vitamin D and calcium intakes and the development of t2dm was explored over a 20-year period women with the highest vitamin D intake from supplements demonstrated a 133% lower risk of developing t2dm
Compared to those with the lowest intake the protective effect was even more pronounced when vitamin D was combined with calcium V vitamin D and immune system vitamin D’s involvement in immune system regulation has prompted researchers to delve into two interconnected research Avenues first they explore whether vitamin D deficiency contributes to the
Onset of autoimmune diseases like multiple sclerosis and type 1 diabetes where the immune system erroneously attacks the body’s own organs and tissues second scientists investigate whether Vitamin D supplements could enhance the body’s immune defenses to combat infectious diseases such as tuberculosis and seasonal flu multiple sclerosis the incidence of multiple
Sclerosis Ms is on the rise globally and while the precise cause remains unclear a combination of genetic predisposition and environmental factors including insufficient vitamin D and UVB exposure has been identified as increasing the risk over four decades ago vitamin D was first proposed as a potential factor in Ms development spurred by observations
That Ms rates were notably higher at latitudes far from the equator and lower in regions with diets rich in fish in a prospective study focusing on dietary vitamin D intake women with a daily intake above 400 IU exhibited a 40% lower risk of developing Ms similarly a study among healthy young
Adults in the US found that white individuals with the highest vitamin D serum levels had a 62% lower risk of developing Ms compared to those with the lowest levels notably this effect was not observed in Black participants possibly due to lower vitamin D levels and fewer black study participant additional prospective
Studies conducted in Sweden and Finland reveal the 61% lower risk of Ms with higher serum vitamin D levels and a 43% increased risk of Ms with low serum vitamin D levels respectively among young adults in individuals already diagnosed with Ms higher vitamin D levels have been associated with reduced disease activity and
Progression cumulatively the existing evidence strongly suggests that low vitamin D levels May play a causal role in Ms if this is indeed the case correcting vitamin D insufficiency could potentially prevent around 40% of Ms cases recent findings indicating that genetically determined low vitamin D levels predict a higher risk of multiple
Sclerosis further strengthen the connection between vitamin D and the development of this autoimmune disease seasonal flu and vitamin D the seasonality of flu outbreaks peaking in Winter and subsiding in summer prompted a hypothesis by a British doctor suggesting a sunlight related seasonal stimulus as a trigger for influenza over 20 years later scientists
Proposed that vitamin D might be the key seasonal stimulus among the evidence supporting this hypothesis vitamin D levels are lowest in the winter months the active form of vitamin D tempers the damaging inflammatory response of some white blood cells while it also boosts immune cells production of microb fighting
Proteins children who have vitamin D deficiency rickets are more likely to get respiratory infections while children exposed to sunlight seem to have fewer respiratory infections adults who have low vitamin D levels are more likely to report having had a recent cough cold or upper respiratory tract infection a randomized controlled trial
Conducted in Japanese school children aimed to investigate whether daily Vitamin D supplements could prevent seasonal flu the trial followed nearly 340 children over months during the peak of the winter flu season half of the participants received pills containing 1,200 IU of vitamin D while the other half received Placebo
Pills the researchers observed that the rate of type A influenza in the vitamin D group was approximately 40% lower than in the placebo group with no significant difference in type B influenza rates while other randomized controlled trials exploring the potential of vitamin D in preventing various acute respiratory
Infections have yielded mixed results a comprehensive metaanalysis of individual participant data indicated that daily or weekly vitamin D supplementation can reduce the risk of acute respiratory infections this effect was particularly notable for individuals with very deficient vitamin D levels the findings from this metaanalysis have prompted consideration
Of the potential role of low vitamin D levels in increasing the risk or Verity of Novel Corona virus 2019 covid-19 infection although there is no direct evidence due to the novelty of the disease maintaining adequate vitamin D levels is recommended for various reasons individuals with darker skin or
Limited sun exposure who may be at risk of lower vitamin D levels are advised to consider a supplement of 1,000 or 2,000 IU per day this dosage is now included in many standard multiple vitamin supplements and is coste effective it’s important to note that more research is needed before
Definitively concluding that vitamin D protects against the flu and other acute respiratory infections even if vitamin D provides some benefits it should not be a substitute for getting a flu shot additionally for limiting the risk of covid-19 adhering to careful social distancing and practicing thorough hand hygiene remains crucial
Vitamin D and type 1 diabetes type 1 diabetes t1d displays significant Geographic variability with a child in Finland being around 400 times more likely to develop t1d than a child in Venezuela while genetic factors likely contribute to this variation some studies suggest that t1d rates are lower in sunnier
Regions early evidence hinting at a potential role of vitamin D and t1d come comes from a 30-year study in Finland that monitored over 10,000 children from birth the study found that children who regularly received Vitamin D supplements during infancy had a nearly 90% lower risk of developing type 1 diabetes
Compared to those who did not receive supplements however research exploring the association between dietary vitamin D and t1d as well as trials supplementing children at high risk for t1d with vitamin D has produced mixed and inconclusive results approximately 40% of t1d cases initiate in adulthood but as of now no randomized controlled trials
Specifically examining vitamin D and adult onset t1d have been conducted the feasibility of such trials remains uncertain and further research is needed in this area to provide more conclusive insights into the potential link between vitamin D and the development of type 1 diabetes in adulthood tuberculosis historically before the era
Of antibiotics sunlight and sunlamps were integral components of the standard treatment for tuberculosis TB more recent research has explored the potential link between the sunshine vitamin vitamin D and the risk of TB several case control studies when collectively analized suggest that individuals diagnosed with tuberculosis tend to have lower vitamin D levels
Compared to healthy individuals of similar age and other characteristics other autoimmune disease the vitamin D and omega-3 trial vital a randomized double blind Placebo controlled trial tracking over 25,000 men and women aged 50 and older revealed noteworthy findings regarding vitamin D supplementation the trial showed that taking Vitamin D supplements at a dosage
Of 2,000 iu/day for 5 years either alone or in combination with Marine omega-3 fatty acids 1,000 mg per day led to a reduction in the incidence of autoimmune diseases by approximately 22% compared to a placebo the autoimmune conditions observed included rheumatoid arthritis psoriasis polymyalgia aromatica and autoimmune thyroid diseases such as
Hashimoto’s thyroiditis and Graves disease the doses administered in these supplements are readily available and generally well tolerated the outcomes of the vital trial suggest a potential benefit of vitamin D supplementation in mitigating the risk of various autoimmune conditions however the authors emphasize the need for additional trials to further assess the effectiveness of
These supplements and to confirm the observed reductions in autoimmune disease incidents This research contributes valuable insights into the potential role of vitamin D in modulating the immune system and its imp impact on autoimmune conditions encouraging further exploration in this area reduction in overall mortality a compelling report in The
Archives of internal medicine suggests that vitamin D supplementation May reduce overall mortality rates a combined analysis of multiple studies encompassing data from 18 randomized controlled trials with nearly 60,000 participants indicated a statistically significant 7% reduction in mortality from any cause with modest levels of Vitamin D supplements the majority of participants
Took between 4800 IU of vitamin D per day for an average of 5 years vitamin D and cognitive functions in an analysis involving over 427,000 white European participants using mandelian randomization it was found that individuals with low vitamin D blood had a 54% higher risk of dementia compared compared to those with
Adequate levels this approach which employs genetic variations to establish causal relationships helps provide robust evidence linking low vitamin D levels to an increased risk of cognitive decline and dementia the findings underscore the potential importance of maintaining sufficient vitamin D levels for cognitive Health thank you for watching this
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