Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare immune reaction in response to the administration of an adenviral vector vaccination. During the height of the pandemic, misinformation regarding VITT was a prominent issue. This video aims to provide background knowledge on VITT while debunking some myths regarding the condition’s causal relationship with COVID-19 vaccines, occurrence, and treatment. This video will also cover the mechanism behind thrombosis, diagnostic criteria, symptomatology, treatment, and epidemiology.
This video was made by McMaster University students Laura Venier, Abesha Kuperan, Gurleen Sodhi, and Aashna Agarwal in collaboration with the Demystifying Medicine McMaster Program.
This video is provided for general and educational information only. Please consult your healthcare provider for more information.
Copyright McMaster University 2023.
#demystifyingmedicine #VITT #thrombocytopenia #covid19
References:
Adverse Events Following Immunization (AEFIs) for COVID-19 in Ontario: December 13, 2020 to October 23, 2022:32 (n.d.). Retrieved November 9, 2022, from https://www.publichealthontario.ca/-/media/documents/ncov/epi/covid-19-aefi-report.pdf?sc_1ang=en
Aleem, A., & Nadeem, A. J. (2022). Coronavirus (COVID-19) Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT). In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK570605/
Understanding vaccine-induced thrombotic thrombocytopenia (VITT). Internal Medicine Journal, 52(5), 717-723. https://doi.org/10.1111/imj.15783
Elberry, M. H., Abdelgawad, H. A. H., Hamdallah, A, Abdella, W. S., Ahmed, A. S., Ghaith, H. S., & Negida, A (2022). A systematic review of vaccine-induced thrombotic thrombocytopenia in individuals who received COVDI-19 adenoviral-vector based vaccines. Journal of Thrombosis and Thrombolysis, 53(4), 798-823. https://doi.org/10.1007/s11239-021-02626-w
Klok, F. A., Pai, M., Huisman, M. V., & Makris, M. (2022). Vaccine-induced immune thrombotic thrombocytopenia. The Lancet Haematology, 9(1), e73-e80. https://doi.org/10.1016/S2352-3026(21)00306-9
Thrombosis with Thrombocytopenia Syndrome-Hematology.org. (2022). Retrieved November 9, 2022. from https://www.hematology.org:443/covid-19/vaccine-induced-immune-thrombotic-thrombocytopenia
Warkentin, T.E. (2022). Platelet-activating anti-PF4 disorders: An overview. Seminars in Hematology, 59(2), 59-71. https://doi.org/10.1053/j.seminhematol.2022.02.005
