The COVID-19 pandemic has prompted scientists to use adaptive research designs to evaluate potential treatments simultaneously and efficiently, increasing the likelihood that patients will receive treatments most likely to be effective for them. Lennie Derde, MD of @UMC Utrecht and Chris Seymour, MD of @UPMC join JAMA’s Q&A series to discuss the latest in critical care management of COVID-19 patients and emerging treatment strategies and therapies.
Originally broadcast January 13, 2021
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Topics discussed in this interview:
0:00 Introduction
1:07 COVID-19 in Utrecht, Netherlands
2:43 COVID-19 in Pittsburgh, PA
3:43 Current standards of care for critically ill patients
6:10 Ventilator use and intubation concerns
8:36 Interleukin-6 receptor antagonists in critically ill patients with COVID-19
10:10 Usage of sarilumab and ticilizumab
13:32 Usage of anticoagulants and concerns
16:31 Mitigating patient transfer to ICU
19:23 Convalescent plasma
19:56 Differences in defining “moderate” and “mild”
20:23 Usage of remdesivir in the US vs internationally
21:42 Outlook for critical care
24:37 Clinical progression in COVID-19
27:56 Long haulers
30:55 Projected mortality rates
33:46 Influences on long term research
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