Vitamin B1 (thiamine) : Sources, Active form, Functions, Absorption, Transportation and Deficiency
Water-soluble: metabolic vitamins B1 through B7 (no B4; adenine is B4 and isn’t considered a B vitamin anymore)
Vit B1 (thiamine): one of its derivatives, thiamine pyrophosphate, is a cofactor for several dehydrogenase enzymes that work on α-ketoacids (e.g. pyruvate, α-ketoglutarate)
Deficiency → beriberi, Wernicke-Korsakoff syndrome
Beriberi has a dry (neuropathy) and wet (high output heart failure) component.
Wernicke-Korsakoff is a syndrome of Wernicke’s encephalopathy (a triad of confusion, ophthalmoplegia, and ataxia) and Korsakoff’s psychosis (memory loss, confabulation and personality change).
#thiamine #tpp #vitaminB1 #Bcomplexvitamins #vitamins #vitaminsbiochemistry #usmlebiochemistry #usmlestep1 #usmle #vitaminb1sources #vitaminb1synthesis #vitaminb1beriberi #vitaminb1metabolism #vitaminb1functions
