Did you know that both type 2 and type 1 diabetics waste thiamine through the kidneys at an exponentially higher rate than the average person?
Diabetics were shown in one study to have 75% lower plasma thiamine than controls.
The pancreas is a rich store of thiamine, and requires sufficient levels to secrete insulin and glucagon. In a deficiency, insulin secretion drops quite significantly.
In the context of hyperglycemia, when cells experience “energetic overload”, a buildup of glucose in the cell yields a variety of inflammatory products which are the primary causes of injury in diabetes. Thankfully, high dose thiamine supplementation can resolve these issues and improve overall diabetic biomarkers.
In this video I explain how thiamine deficiency is common in diabetes, and examine some of the mechanisms by which low thiamine status may facilitate diabetic complications. I also show thiamine supplementation can resolve some of these issues.
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