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RESTRICTIONS: Broadcast: NO USE JAPAN, NO USE TAIWAN Digital: NO USE JAPAN, NO USE TAIWAN
Pfizer and German company BioNTech announced on Monday, November 9, that their coronavirus vaccine is more than 90 percent effective in preventing COVID-19 in those who have not previously been infected with the virus.
Reuters reports that Pfizer and BioNTech said they have found no serious safety concerns and expect to seek U.S. emergency use authorization this month.
Phases 3 clinical trials enrolled 43,000 participants and reported only 94 lab-confirmed COVID-19 infections.
Each vaccine requires two doses. Pfizer and BioNTech said if granted authorization, they could produce up to 50 million doses in 2020. Then they could produce 1.3 billion does in 2021.
This animation explains how the vaccine works.
RUNDOWN SHOWS:
1. Vaccine is based on the genetic sequence of the novel coronavirus
2. Vaccine packages mRNA into a lipid nanoparticle carrier
3. mRNA instructs a cell to produce the coronavirus’s spike protein
4. Spike protein is then displayed on the surface of the cell and triggers an immune system response
VOICEOVER (in English):
“An mRNA vaccine is based on the genetic sequence of the novel coronavirus, and not the actual virus. mRNA is short for ‘messenger RNA.'”
“Pfizer and BioNTech’s SARS-CoV-2 vaccine uses the genetic blueprint for the ‘spike’ protein that coats the virus, according to information published on Pfizer’s website. The spike protein is used to synthesize an mRNA sequence.”
“This is packaged into a lipid nanoparticle carrier. Lipid nanoparticles protect the mRNA from degradation inside the body and facilitate its delivery to the targeted cells.”
“The lipid nanoparticle carrier transfers the mRNA and its copies of genetic instructions
to the cytoplasm of a cell, where the ribosomes are found.”
“Once inside the cell, the mRNA instructs the ribosomes to produce the coronavirus’s spike protein. By itself, the spike protein is harmless.”
“The spike protein is then displayed on the surface of the cell. This simulates a coronavirus infection, thus triggering the body to mount an immune system response.”
SOURCES: Pfizer, CNBC, Reuters
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