Nutrition and Metabolism 17: The biosynthesis of vitamin K (menaquinone) from molecules produced in the shikimate pathway and the polyprenyl pyrophosphates.
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References and Resources:
Vitamin K Fact Sheet:
Vitamin K Biosynthesis Mechanisms:
Biosynthesis of Menaquinone (Vitamin K2) and Ubiquinone (Coenzyme Q):
Lysine 190 Is the Catalytic Base in MenF, the Menaquinone-Specific Isochorismate Synthase from Escherichia coli: Implications for an Enzyme Family:
An Open and Shut Case: The Interaction of Magnesium with MST Enzymes:
MenF Mechanism:
An isochorismate hydroxymutase isogene in Escherichia coli:
Molecular Basis of the General Base Catalysis of an / -Hydrolase Catalytic Triad:
Vitamin K2 in Electron Transport System: Are Enzymes Involved in Vitamin K2 Biosynthesis Promising Drug Targets?
Host-pathogen biotic interactions shaped vitamin K metabolism in Archaeplastida:
Evolution of Enzymatic Activity in the Enolase Superfamily: Structural Studies of the Promiscuouso-Succinylbenzoate Synthase from Amycolatopsis:
Evolution of Enzymatic Activities in the Enolase Superfamily: N-Succinylamino Acid Racemase and a New Pathway for the Irreversible Conversion of D-to L-Amino Acids:
o-Succinylbenzoyl-CoA (OSB-CoA) synthetase (MenE):
Structural Basis of the Induced-Fit Mechanism of 1,4-Dihydroxy-2-Naphthoyl Coenzyme A Synthase from the Crotonase Fold Superfamily:
Crystal Structures of E. coli Native MenH and Two Active Site Mutants:
Crystal Structure of Mycobacterium tuberculosis MenB, a Key Enzyme in Vitamin K2 Biosynthesis:
Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism:
Chorismate Biosynthesis:
Lysine221 is the general base residue of the isochorismate synthase from Pseudomonas aeruginosa (PchA) in a reaction that is diffusion limited:
Unraveling the structure and mechanism of the MST(ery) enzymes:
Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms:
