Nutrition and Metabolism 16: The biosynthesis of vitamin E (alpha tocopherol and gamma tocopherol). The enzymatic mechanisms, structures, and kinetics of the shikimate pathway are covered in great detail. The EPSP synthase step covers the inhibition by glyphosate.
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References and Resources:
Vitamin E Fact Sheet:
Properties:
Vitamin E Biosynthesis and Its Regulation in Plants:
Shikimic acid: A highly prospective molecule in pharmaceutical industry:
pH Dependence of Catalysis by Pseudomonas aeruginosa Isochorismate-Pyruvate Lyase: Implications for Transition State Stabilization and the Role of Lysine 42:
Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis:
Separation of inhibition and activation of the allosteric yeast chorismate mutase:
A glutamate residue in the catalytic center of the yeast chorismate mutase restricts enzyme activity to acidic conditions:
Allosteric Regulation of Catalytic Activity: Escherichia coli Aspartate Transcarbamoylase versus Yeast Chorismate Mutase:
Molecular Biotechnology for Nutraceutical Enrichment of Food Crops: The Case of Minerals and Vitamins: Vitamin A and E pathway –
Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS:
Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis:
Mevalonate Pathway (Wikipedia):
Interaction of the herbicide glyphosate with its target enzyme 5-enolpyruvylshikimate 3-phosphate synthase in atomic detail:
5-Enolpyruvylshikimate-3-phosphate synthase from Staphylococcus aureus is insensitive to glyphosate: file:///C:/Users/Tom/AppData/Local/Temp/1-s2.0-S0014579305000128-main.pdf
Efficient metabolic pathway engineering in transgenic tobacco and tomato plastids with synthetic multigene operons:
Genetic variation of γ-tocopherol methyltransferase gene contributes to elevated α-tocopherol content in soybean seeds:
Characterization of c-tocopherol methyltransferases from Capsicum annuum L and Arabidopsis thaliana:
