Coronavirus Vaccine Update: Moderna Vaccine | Moderna Vaccine Update | Moderna | mRNA #shorts #short #modernavaccine | Coronavirus Vaccine Short Update: Moderna Vaccine | Moderna Vaccine Update | Moderna
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Moderna said Monday its vaccine was 94.5% effective in a preliminary analysis. That compares favorably with the lofty level achieved a week earlier by Pfizer and its partner, BioNTech SE. The shot created by the U.S. and German companies was found to be more than 90% effective. Moderna data showed that side effects were generally short-lived and there were no significant safety concerns, while no serious Covid cases developed among trial participants who got the vaccine. U.S. regulators earlier this year released guidance that said any shot should be at least 50% effective.
“The Moderna vaccine is a much more viable option for low- and middle-income countries than the Pfizer vaccine,” said Rachel Silverman, from Center for Global Development said.
One of the biggest challenges to delivering a promising coronavirus vaccine based on unprecedented technology to millions around the world just got easier.
When Pfizer Inc. announced effective preliminary results for its vaccine candidate last week, the downside was that it must be stored at ultra-cold temperatures, posing significant logistical issues. But Moderna Inc. on Monday one-upped its rival, offering a vaccine based on the same technology that appears to be equally effective, but which also can be stored at regular refrigerated temperatures for up to a month.
The difference is significant. Delivering normal vaccines to populations in the remotest regions from India to Africa is difficult enough just on supply and transport issues. The temperature factor introduces a more daunting hurdle, requiring countries to build storage and transportation networks that can maintain temperatures far colder than that required for frozen meat. The massive investment and coordination needed raised the likelihood that only rich nations would be guaranteed access.
“The Moderna vaccine is a much more viable option for low- and middle-income countries than the Pfizer vaccine,” said Rachel Silverman, a Washington-based policy fellow at the Center for Global Development. “Cold-storage needs are less extreme.”
Not only can Moderna’s vaccine remain stable in the fridge for 30 days, it can also be kept in ordinary freezers for long-term use. Pfizer’s vaccine has to be kept at negative 70 degrees and could only be refrigerated for up to five days — at least until its researchers are able to match Moderna’s breakthrough.
“The Moderna vaccine can be accommodated within the existing vaccine distribution networks,” said Ayfer Ali, an assistant professor and specialist in drug research at Warwick Business School in the U.K. “Even in remote and underdeveloped areas, fridges are available or can be supplied cheaply.”
Although Moderna has only cut deals with a handful of developed countries for its vaccine, it received funding from the nonprofit Coalition for Epidemic Preparedness Innovations and may therefore be bound to help enable access in low-middle income countries, said Silverman.
Moderna received $955 million from the U.S. Operation Warp Speed program. Pfizer has said it didn’t receive any federal funding to develop its vaccine, though BioNTech got as much as 375 million euros ($444 million) in German government assistance. Still, Pfizer has struck a supply agreement with the U.S. worth nearly $2 billion. The U.S. has agreed to pay up to $1.53 billion to purchase supply of the Moderna shot.
Vaccine from Moderna is second to exceed expectations in a pivotal trial.
Moderna Inc’s experimental vaccine was 94.5% effective in preventing COVID-19 based on interim data from a late-stage trial, the company said on Monday.
Both vaccines employ synthetic messenger RNA (mRNA), which coaxes cells to make certain virus proteins that the immune system sees as a threat and mounts a response against.
Moderna expects it to be stable at normal refrigerator temperatures of 2 to 8 degrees Celsius (36 to 48°F) for 30 days and can be stored for up to 6 months at -20C.
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