In this video we will discuss an article published exploring a new possible signaling mechanism that SARS-CoV-2 sparks that may explain many of the findings that occur with severe COVID-19. This is the STAT3 and PAI-1 pathway. This pathway is involved in coagulopathy/thrombosis, hypoxia and pulmonary fibrosis, cytokine release, and lymphopenia. All of these may sound very similar as they are all complications that we have been seeing with severe COVID-19! The interesting thing here and the focus of this video is that Ivermectin in vitro has been shown to down regulate this pathway through PAK1. Could this explain why studies are seeing efficacy with Ivermectin for both early disease (anti-viral) and severe disease (immunomodulatory)? Check out the video as we discuss this pathway and Ivermectin’s role!
Link to study:
Ivermectin Videos:
IVM, Nitazoxanide, Hydroxychloroquine and COVID-19:
Four Different Mechanisms of Action Of IVM:
Ivermectin, Azithromycin, And Vitamin D Early Outpatient COVID-19:
Ivermectin And The STAT3 Pathway: A New Mechanism Of Action:
Randomized, Double Blinded Placebo Controlled Trial IVM+Doxycycline:
IDEA Trial (Ivermectin, Dexamethasone, Enoxaparin, Aspirin) Mild, Mod, Sever COVID:
Ivermectin to Treat Hospitalized Patients with COVID-19:
IVERCAR (Ivermectin and Carrageenan Prophylaxis):
Ivermectin Inhibits RNA Dependent RNA Polymerase
Ivermectin Post-Exposure Prophylaxis:
Ivermectin Prophylaxis For COVID-19:
Ivermectin and Doxycycline To Treat Mild to Moderate COVID-19:
Ivermectin, Hydroxychloroquine, and Azithromycin for Hospitalized COVID-19 patients:
Ivermectin and new mechanism; halting thrombi through inhibition of CD147:
ICON Trial:
Clinical Trial on Ivermectin (data may be falsified):
In Vitro on Ivermectin for COVID-19, 99.99% Decrease in Viral Load:
Ivermectin+Doxycyline Compared to Hydroxychloroquine+Azithromycin for COVID-19:
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There will be a running series of videos using the most up to date information on COVID-19, but this is an evolving field and new videos may come out that contradict that previous information. That is okay and is the nature of a fast paced and evolving clinical scenario. Stick with us as we work to unveil the intricacies of COVID-19, it’s clinical significance, and the societal implications. ***This is strictly educational and not to be mistaken as clinical recommendations, please verify all information with accepted guidelines and practice patterns.***
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THIS VIDEO DOES NOT PROVIDE MEDICAL ADVICE. The information, including but not limited to, text, graphics, images and other material contained on this website are for informational purposes only. No material on this site is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of something you have read, watched, or listened to on this video, or any other videos, reports, texts tweets or other sources.
