Seasonal Coronavirus Specific Antibodies and The Severity of COVID-19
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Original antigenic sin
Cross-reactivity
Severe COVID-19 patients display a back boost of seasonal coronavirus-specific antibodies
Less severe course of COVID-19 is associated with elevated levels of antibodies against seasonal human coronaviruses OC43 and HKU1 (HCoV OC43, HCoV HKU1)
How antigenic sin reduces the innate response?
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