Leading COVID-19 vaccine candidates rely on new genetic technologies that have fast-tracked development and testing. This video explains the principles underlying the leading DNA, messenger RNA (mRNA), and viral vector vaccine candidates, and how they might induce immunity to SARS-CoV-2 infection.
0:00 Introduction
1:21 Traditional vaccines
2:00 COVID-19 vaccine types in development
2:18 Making vaccines from a genetic sequence
2:45 Target antigen: the S protein
3:32 Genetic vaccines (DNA and mRNA)
4:18 Moderna/NIH and Pfizer/BioNTech vaccines
4:52 Viral vector vaccines
5:42 Adenovirus vectors (University of Oxford/AstraZeneca and Johnson & Johnson/Janssen Pharmaceuticals)
6:32 rVSV vector vaccine (Merck/IAVI)
7:15 Previous experience with next generation vaccines
7:50 Importance of Phase 3 Trials
For full livestreams featured in this video:
Anthony S. Fauci, MD, January 27, 2020:
Paul A. Offit, MD, June 1, 2020:
Robert Redfield, MD, July 14, 2020:
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