Beyond antibodies, the immune response to coronavirus is complicated,Keyword,Ultimately, the only way for societies to return to some semblance of normal in the wake of the current pandemic is to reach a state called herd immunity. This is where a large-enough percentage of the population has acquired immunity to SARS-CoV-2—either through infection or a vaccine—that most people exposed to the virus are already immune to it. This will mean that the infection rate will slow and eventually fizzle out, protecting society as a whole. Given that this is our ultimate goal, we need to understand how the immune system responds to this virus. Most of what we know is based on a combination of what we know about other coronavirus that infect humans and the antibody response to SARS-CoV-2. But now, data is coming in on the response of T-cells, and it indicates that their response is more complex: longer-lasting, broadly based, and including an overlap with the response to prior coronavirus infections. What this means for the prospect of long-lasting protection remains unclear. What we know now SARS-CoV-2 is one of seven coronaviruses known to infect humans. Some of these, like SARS and MERS, have only made the jump to humans recently. While more lethal than SARS-CoV-2, we are fortunate that they spread among humans less efficiently. These viruses seem to provoke a long-lasting immune response following infections. That’s a sharp contrast to the four coronaviruses that circulate widely with humans, causing cold-like symptoms. These viruses induce an immunity that seems to last less than a year. We don’t know much about the immune response to SARS-CoV-2 yet. By tracking the production of antibodies, it’s clear that many of those infected do have a robust immune response, but “many” is far from “all”—there’s a lot of variability in the level of response. That variability is associated with a large difference in the severity of COVID-19 among patients. One area of concern is that the antibody response to SARS-CoV-2 appears to decline rapidly. The antibody response, however, is only one part of the immune system’s defense against a pathogen. Antibodies typically recognize the proteins that reside on the surface of a virus, since those are the ones that the cells that make antibodies are exposed to. But a second group of cells, called T-cells, have a different way of recognizing pathogens. T-cells rely on a system used by all cells, which takes small pieces of the proteins they are making and presents them on the cell surface. Because of how the system works, it has the potential to recognize more of the proteins made by a virus—not just the ones on its surface. (Some immune cells that swallow pathogens also put protein fragments on their surface in the same way.) Once there, any T-cells that recognize these small pieces of protein as foreign can mount a variety of responses, from activating their fellow immune cells to killing the cell that is making foreign proteins. Studying the T-cell response is much more challenging, since it’s based on cells, rather than antibodies, which are proteins. But such study can be equally critical to long-term immunity. Studying the Ts To study the T-cell response, a group of researchers based in Singapore focused on proteins that are either internal to the virus or used only in the cells it infects and thus aren’t a major focus of the antibody response. To check the response to these proteins, the researchers made a set of 15-amino-acid-long protein fragments that, collectively, span the entire length of the protein. They then collected blood cells from people who had recovered from COVID-19, those who recovered from the original SARS, and those who have never been exposed to either virus. These fragments were pooled and mixed with blood cells to determine whether any T-cells within them reacted to them. By narrowing down the pools, the researchers were able to identify the specific fragment—and thus the specific region of the protein it came from—that T-cells were responding to. The response was registered by checking the level of an immune-signaling molecule produced by T-cells. One of the potentially reassuring findings was that people who had been exposed to the original SARS virus 17 years earlier still had T-cells that responded to fragments of the virus. This was true even though the antibody response to this virus had generally faded after several yea..
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