COVID-19

Oestrogen and COVID severity in women

Men and older women have been shown to be at higher risk of adverse outcomes

Variables

Menopausal status

COCP (Combined Oral Contraceptive Pill)

HRT (Hormone Replacement Therapy)

152,637 women for menopause status

295,689 for COCP use

151,193 for HRT use

Results corrected for

Age

Smoking

BMI

Results

Post-menopausal women aged 40-60 years

More diagnosed cases

More symptoms

Trend (but not significant) to increased disease severity

Women aged 18-45 years taking COCP

Significantly lower prevalence of COVID-19 diagnosis

Reduction in hospital attendance (P = 0.023)

Post-menopausal women using HRT

Increased rates of COVID-19

No increase in hospitalization