Vitamin D has a curvilinear effect, in that too little is not good, and too much is not good. When we have blood levels that are in the optimal range, our immune system can perform as needed. In fact, vitamin D can act as both an anti-inflammatory and have a pathogen-killing effect. In one study, vitamin D lowered MMP9 by 68% (a very destructive molecule), TIMP-1 by 38%, CRP by 23% (QJM. 2002 Dec;95(12):787-96). It can also induce macrophage activity.@grassrootshealth, one of my trusted sources for vitamin D research, recommends ensuring blood levels are between 100-150 nmol/L (40-60 ng/mL). You can test by ordering a kit directly from them (which also enrolls you in their research), or getting your Doc to requisition it. @Everlywell also ships kits direct to consumer. (I have no vested interest in either companies). Government organizations typically recommend 400-800 iu/day of vitamin D. I have found that my clients need between 2000-10,000 iu/day to stay within the optimal range.
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