“Because of the modifications, which fool the cell, the resulting viral messenger RNA is now considered as part of the cell’s own code and not foreign,” lead author Yogesh Gupta of the University of Texas Health Science Center at San Antonio (UT Health San Antonio) said in a statement.
Deciphering the 3D structure of nsp16, Dr Gupta said, paves the way for rational design of antiviral drugs for Covid-19 and other emerging coronavirus infections.
This is a fundamental advance in our understanding of the virus,” said study co-author Robert Hromas, professor and dean of the Long School of Medicine at UT Health San Antonio.
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